T4TE Project 1
Motor TMS-Evoked Potentials (M1-TEPs)
Project overview
The T4TE Project 1 aims at investigating the reliability, validity and possible biomarkers development of the TMS-Evoked Potentials (TEPs) elicited by stimulating the primary motor cortex (M1) through multiple studies
Study 1.1 Reliability of M1-TEPs
Progress: Drafting Registered Report Stage 1. Stay tuned!
Study overview
The main aim of Study 1.1 is testing the reliability of TEPs elicited by stimulating M1 to variations in procedures across labs. Specifically, Study 1.1 is designed to disentangle the effects of flexibility in data acquisition and in data processing on TEPs. Moreover, it will investigate the direct effect of flexibility on: a) the comparison of TEPs in trials of high and low cortical excitability, as indexed by motor-evoked potentials (MEPs), and b) the effect of prestimulus oscillations on TEPs.
Status
Study 1.1 is currently working on the preparation of Ethics documentation and the Registered Report Stage 1.
Leads
Contribute
Participation in T4TE - Study 1.1 is open to single researchers, research groups and labs, who can join either collecting or analysing data or both.
Requirements for data acquisition
Meet the minimum criteria in equipment settings for TMS-EEG coregistration:
TMS: Monophasic or biphasic TMS with standard figure-of-eight coil
EEG: Sampling rate > 4000 Hz, High-pass filter: DC recording or < 0.1 Hz, Low-pass filter > 1000 Hz; Channels > 60 passive or active placed according to the 10-10 International EEG system
EMG: At least 3 bipolar channels, Sampling rate > 1000 Hz
Commitment to collect 25 young healthy participants
Show evidence of high-quality data collection in the “quality check” phase of the study (before data collection)
Provide a detailed report on the acquisition procedures
Share the raw data and meta-files in open repositories
Requirements for data analyses
Commitment to analyse three datasets (of which at least two recorded from other labs)
Provide a detailed report of the analyses pipeline
Show evidence of quality checks before performing the analyses
Share codes and preprocessed data in open repositories
If you do not meet the requirements but would like to contribute, please let us know.
Authorship
3 authors for participating in data collection only
1 author for participating in data analysis only
4 authors for participating in both data collection and analysis
Tentative timeline
September - December 2022: Open call for participating labs will be open
January - June 2023: Open discussion of the experimental design
June 2023 - June 2025: Ethics & Registered Report preparation/submission.
June - December 2025: Quality checks
January - September 2026: Data collection
March 2027: Data analyses completed
September 2027: Submission of stage 2 Registered Report
Participating Labs
